The majority of risk loci identified by genome-wide association studies (GWAS) are in non-
coding regions, hampering their functional interpretation. Instead, transcriptome-wide …

Background The addition of ezetimibe to statin therapy has been widely demonstrated to
significantly reduce low-density lipoprotein cholesterol levels. However, the efficacy of …

Rationale: Therapies that inhibit CETP (cholesteryl ester transfer protein) have failed to
demonstrate a reduction in risk for coronary heart disease (CHD). Human DNA sequence …

Cholesterol plays critical functions in arranging the biophysical attributes of proteins and
lipids in the plasma membrane. For various viruses, an association with cholesterol for virus …

A fine-tuned balance between cholesterol uptake and excretion by the body is pivotal to
maintain health and to remain free from the deleterious consequences of cholesterol …

Background: Exposure to plastic-associated endocrine disrupting chemicals (EDCs) has
been associated with an increased risk of cardiovascular disease (CVD) in humans …

The purpose was to develop, optimize and assess Self-nanoemulsifying drug delivery
system (SNEDDS) to enhance solubility and dissolution rate of the poorly-water soluble …

Personalized medicine is an emerging concept involving managing the health of patients
based on their individual characteristics, including particular genotypes. Cardiovascular …

Abstract Purpose of Review The purpose of this review is to discuss dyslipidemia in the
various common clinical conditions including hypertension, diabetes mellitus, and metabolic …

Familial hypercholesterolemia (FH) is a common genetic cause of premature cardiovascular
disease (CVD). The reported prevalence rates for both heterozygous FH (HeFH) and …