Polymeric amorphous solid dispersions: a review of amorphization, crystallization, stabilization, solid-state characterization, and aqueous solubilization of …

S Baghel, H Cathcart, NJ O'Reilly - Journal of pharmaceutical sciences, 2016 - Elsevier
Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …

[HTML][HTML] Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application

MF Simões, RMA Pinto, S Simões - Drug Discovery Today, 2019 - Elsevier
The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

Physical stability of amorphous solid dispersions: a physicochemical perspective with thermodynamic, kinetic and environmental aspects

X Lin, Y Hu, L Liu, L Su, N Li, J Yu, B Tang… - Pharmaceutical …, 2018 - Springer
Abstract Purpose Amorphous solid dispersions (ASDs) have been widely used in the
pharmaceutical industry for solubility enhancementof poorly water-soluble drugs. The …

Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development

A Butreddy, S Bandari, MA Repka - European Journal of Pharmaceutical …, 2021 - Elsevier
An industrially feasible approach to overcome the solubility and bioavailability limitations of
poorly soluble active pharmaceutical ingredients is the development of amorphous solid …

Considerations for the selection of co-formers in the preparation of co-amorphous formulations

DL Yarlagadda, VSK Anand, AR Nair, KSN Sree… - International Journal of …, 2021 - Elsevier
Co-amorphous drug delivery systems are evolving as a credible alternative to amorphous
solid dispersions technology. In Co-amorphous systems (CAMs), a drug is stabilized in …

The application of modeling and prediction to the formation and stability of amorphous solid dispersions

K DeBoyace, PLD Wildfong - Journal of Pharmaceutical Sciences, 2018 - Elsevier
Amorphous solid dispersion (ASD) formulation development is frequently difficult owing to
the inherent physical instability of the amorphous form, and limited understanding of the …

Theoretical and experimental investigation of drug-polymer interaction and miscibility and its impact on drug supersaturation in aqueous medium

S Baghel, H Cathcart, NJ O'Reilly - European Journal of Pharmaceutics and …, 2016 - Elsevier
Amorphous solid dispersions (ASDs) have the potential to offer higher apparent solubility
and bioavailability of BCS class II drugs. Knowledge of the solid state drug-polymer …

Self emulsifying drug delivery system for enhanced solubility and dissolution of glipizide

AG Agrawal, A Kumar, PS Gide - Colloids and Surfaces B: Biointerfaces, 2015 - Elsevier
The aim of this study was to develop self emulsifying drug delivery systems (SEDDS) of
glipizide and to convert it into solid SEDDS (S-SEDDS) using Syloid® 244 FP as adsorbent …

Cilostazol-loaded poly (ε-Caprolactone) electrospun drug delivery system for cardiovascular applications

M Rychter, A Baranowska-Korczyc, B Milanowski… - Pharmaceutical …, 2018 - Springer
Purpose The study discusses the value of electrospun cilostazol-loaded (CIL) polymer
structures for potential vascular implant applications. Methods Biodegradable …

Physicochemical properties of tadalafil solid dispersions–Impact of polymer on the apparent solubility and dissolution rate of tadalafil

K Wlodarski, W Sawicki, K Haber, J Knapik… - European Journal of …, 2015 - Elsevier
To improve solubility of tadalafil (Td), a poorly soluble drug substance (3 μg/ml) belonging to
the II class of the Biopharmaceutical Classification System, its six different solid dispersions …