Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production,
support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate …
support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate …
Ferroptosis, necroptosis, and pyroptosis in gastrointestinal cancers: the chief culprits of tumor progression and drug resistance
X Zhu, S Li - Advanced Science, 2023 - Wiley Online Library
In recent years, the incidence of gastrointestinal cancers is increasing, particularly in the
younger population. Effective treatment is crucial for improving patients' survival outcomes …
younger population. Effective treatment is crucial for improving patients' survival outcomes …
Vina-GPU 2.0: further accelerating AutoDock Vina and its derivatives with graphics processing units
J Ding, S Tang, Z Mei, L Wang, Q Huang… - Journal of chemical …, 2023 - ACS Publications
Modern drug discovery typically faces large virtual screens from huge compound databases
where multiple docking tools are involved for meeting various real scenes or improving the …
where multiple docking tools are involved for meeting various real scenes or improving the …
Mediators of necroptosis: from cell death to metabolic regulation
X Wu, LE Nagy, J Gautheron - EMBO molecular medicine, 2024 - embopress.org
Necroptosis, a programmed cell death mechanism distinct from apoptosis, has garnered
attention for its role in various pathological conditions. While initially recognized for its …
attention for its role in various pathological conditions. While initially recognized for its …
PANoptosis: Emerging mechanisms and disease implications
Z Qi, L Zhu, K Wang, N Wang - Life Sciences, 2023 - Elsevier
PANoptosis, a unique new form of programmed cell death (PCD), is characterized by
pyroptosis, apoptosis, and necroptosis, but it cannot be explained by pyroptosis, apoptosis …
pyroptosis, apoptosis, and necroptosis, but it cannot be explained by pyroptosis, apoptosis …
Unwinding the modalities of necrosome activation and necroptosis machinery in neurological diseases
Necroptosis, a regulated form of cell death, is involved in the genesis and development of
various life-threatening diseases, including cancer, neurological disorders, cardiac …
various life-threatening diseases, including cancer, neurological disorders, cardiac …
[HTML][HTML] Novel insights into the interplay between m6A modification and programmed cell death in cancer
J Chen, M Ye, J Bai, C Hu, F Lu, D Gu… - International journal of …, 2023 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) methylation, the most prevalent and abundant RNA
modification in eukaryotes, has recently become a hot research topic. Several studies have …
modification in eukaryotes, has recently become a hot research topic. Several studies have …
An overview of the past decade of bufalin in the treatment of refractory and drug-resistant cancers: current status, challenges, and future perspectives
Q Ye, X Zhou, H Ren, F Han, R Lin, J Li - Frontiers in Pharmacology, 2023 - frontiersin.org
Profound progress has been made in cancer treatment in the past three decades. However,
drug resistance remains prevalent and a critical challenge. Drug resistance can be attributed …
drug resistance remains prevalent and a critical challenge. Drug resistance can be attributed …
Quercetin inhibits necroptosis in cardiomyocytes after ischemia–reperfusion via DNA‐PKcs‐SIRT5‐orchestrated mitochondrial quality control
X Chang, Q Zhang, Y Huang, J Liu… - Phytotherapy …, 2024 - Wiley Online Library
We investigated the mechanism by which quercetin preserves mitochondrial quality control
(MQC) in cardiomyocytes subjected to ischemia–reperfusion stress. An enzyme‐linked …
(MQC) in cardiomyocytes subjected to ischemia–reperfusion stress. An enzyme‐linked …
RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection
Innate immune signaling in the central nervous system (CNS) exhibits many remarkable
specializations that vary across cell types and CNS regions. In the setting of neuroinvasive …
specializations that vary across cell types and CNS regions. In the setting of neuroinvasive …