Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production,
support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate …

In recent years, the incidence of gastrointestinal cancers is increasing, particularly in the
younger population. Effective treatment is crucial for improving patients' survival outcomes …

Modern drug discovery typically faces large virtual screens from huge compound databases
where multiple docking tools are involved for meeting various real scenes or improving the …

Necroptosis, a programmed cell death mechanism distinct from apoptosis, has garnered
attention for its role in various pathological conditions. While initially recognized for its …

PANoptosis, a unique new form of programmed cell death (PCD), is characterized by
pyroptosis, apoptosis, and necroptosis, but it cannot be explained by pyroptosis, apoptosis …

Necroptosis, a regulated form of cell death, is involved in the genesis and development of
various life-threatening diseases, including cancer, neurological disorders, cardiac …

Abstract N6-methyladenosine (m6A) methylation, the most prevalent and abundant RNA
modification in eukaryotes, has recently become a hot research topic. Several studies have …

Profound progress has been made in cancer treatment in the past three decades. However,
drug resistance remains prevalent and a critical challenge. Drug resistance can be attributed …

We investigated the mechanism by which quercetin preserves mitochondrial quality control
(MQC) in cardiomyocytes subjected to ischemia–reperfusion stress. An enzyme‐linked …

Innate immune signaling in the central nervous system (CNS) exhibits many remarkable
specializations that vary across cell types and CNS regions. In the setting of neuroinvasive …