Autophagy is a well-conserved biological process that maintains homeostasis. Accumulating
evidence has revealed that autophagy plays an important role in various cardiovascular …

Highlights•No medical intervention can completely arrest aneurysmal growth.•Drugs with
immediate translational potential in Marfan syndrome include resveratrol, doxycycline …

Metabolic reprogramming of vascular smooth muscle cell (VSMC) plays a critical role in the
pathogenesis of thoracic aortic dissection (TAD). Previous researches have mainly focused …

Thoracic aortopathy–aneurysm, dissection, and rupture–is increasingly responsible for
significant morbidity and mortality. Advances in medical genetics and imaging have …

Aortic dissection (AD) is a life-threatening disease featured by the dissection of intimal layer
and the formation of a blood-filled false lumen within the aortic wall. Recent studies revealed …

Background Thoracic aortic aneurysm (TAA) is a silent but dangerous cardiovascular
disease. Understanding molecular mechanisms of TAA on single-cell level might provide …

Background Marfan syndrome (MFS) is a genetic disorder leading to medial aortic
degeneration and life-limiting dissections. To date, there is no causal prevention or therapy …

Immunosuppressive drugs are widely and chronically used to avoid graft rejection in
transplant recipients. However, they are also known to have organotoxic effects and can …

Aims In pulmonary fibrosis, autophagy handles the maintenance of alveolar epithelial cells,
prevents epithelial-mesenchymal transition (EMT), and controls collagen turnover. The …

Bestrophin is a superfamily of 4 isoforms of Ca2+-activated Cl− channels expressed
predominantly expressed in the brain, eyes, and gastrointestinal tract. 2 BEST3 is also …