Bilirubin has several physiological functions, both beneficial and harmful. In addition to
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …

Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation
of inflammatory responses is associated with most human diseases. Reactive oxygen …

Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease
with increasing worldwide incidence. It is usually induced by the restoration of normal blood …

Bilirubin levels in obese humans and rodents have been shown to be lower than in their
lean counterparts. Some studies have proposed that the glucuronyl UGT1A1 enzyme that …

Cardiovascular diseases are one of the leading causes of mortality in developed countries.
Among cardiovascular disorders, myocardial infarction remains a life-threatening problem …

Heme oxygenase (HO) has both beneficial and detrimental effects via its metabolites,
including carbon monoxide (CO), biliverdin or bilirubin, and ferrous iron. HO-1 is an …

Coronary heart disease (CHD) is one of the major causes of death and disability worldwide,
especially in low-and middle-income countries and among older populations. Conventional …

Reperfusion therapy is widely used to treat acute myocardial infarction. However, its efficacy
is limited by myocardial ischemia-reperfusion injury (MIRI), which occurs paradoxically due …

Despite the vital importance of monitoring the progression of nonalcoholic fatty liver disease
(NAFLD) and its progressive form, nonalcoholic steatohepatitis (NASH), an efficient imaging …

Common medications for treating inflammatory bowel disease (IBD) have limited therapeutic
efficacy and severe adverse effects. This underscores the urgent need for novel therapeutic …