Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

The liver is a central organ in the human body, coordinating several key metabolic roles. The
structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic …

Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …

Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …

Hepatic fibrogenesis is a pathophysiological outcome of chronic liver injury hallmarked by
excessive accumulation of extracellular matrix proteins. Fibrosis is a dynamic process that …

Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …

Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of
death in the United States. Hepatocyte steatosis is a component of metabolic syndrome and …

The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …