The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

The imbalance between reactive oxygen species (ROS) production and clearance causes
oxidative stress and ROS, which play a central role in regulating cell and tissue physiology …

The AMP-activated protein kinase (AMPK) is a highly conserved master regulator of
metabolism, whose activation has been proposed to be therapeutically beneficial for the …

Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …

Liver fibrosis is a clinically significant finding that has major impacts on patient morbidity and
mortality. The mechanism of fibrosis involves many different cellular pathways, but the major …

Oxidative stress is a reflection of the imbalance between the production of reactive oxygen
species (ROS) and the scavenging capacity of the antioxidant system. Excessive ROS …

Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …

Chronic liver injury, resulted from different etiologies (eg, virus infection, alcohol abuse,
nonalcoholic steatohepatitis (NASH) and cholestasis) can lead to liver fibrosis characterized …

Reactive oxygen species (ROS) are highly reactive oxygen derivatives. Initially, they were
considered as metabolic by-products (of mitochondria in particular), which consistently lead …

Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix
(ECM) in the liver resulting from the persistent liver injury and wound-healing reaction …