Abstract Purpose of the Review This review aims to summarize the current knowledge of the
extracellular matrix remodeling during hepatic fibrosis. We discuss the diverse interactions …

The burden of chronic liver disease is rising substantially worldwide. Fibrosis, characterized
by excessive deposition of extracellular matrix proteins, is the common pathway leading to …

Alcoholic liver disease (ALD)-related fibrosis results from a variety of mechanisms including
the accumulation of acetaldehyde, reactive oxygen species, and hepatic overload of …

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation in the
absence of excessive alcohol consumption and is strongly associated with obesity, type 2 …

Mulberrin (Mul) is a key component of the traditional Chinese medicine Romulus Mori with
various biological functions. However, the effects of Mul on liver fibrosis have not been …

The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is
becoming recognized as key modulators of signal transduction pathways with a …

Liver fibrosis is a pathological wound-healing response caused by chronic liver damage due
to a virus, autoimmune disorder, or drugs. Hepatic stellate cells (HSCs) play an essential …

Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …

Non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic
steatohepatitis (NASH) have emerged as the leading causes of chronic liver disease-related …

The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or
NOX) plays a critical role in the inflammatory response and fibrosis in several organs such …