Nonalcoholic fatty liver disease (NAFLD), characterized by ectopic fat accumulation in
hepatocytes, is closely linked to insulin resistance and is the most frequent complication of …

Liver fibrosis results from many chronic injuries and often progresses to cirrhosis, liver
failure, portal hypertension, and hepatocellular carcinoma. Liver transplantation is the only …

The increased production of derivatives of molecular oxygen and nitrogen in the form of
reactive oxygen species (ROS) and reactive nitrogen species (RNS) lead to molecular …

Liver fibrosis currently represents a global health problem without effective
pharmacotherapeutic strategies. The clinical translation of polydatin, a promising natural anti …

In recent decades, there have been tremendous improvements in burn care that have
allowed patients to survive severe burn injuries that were once fatal. However, a major …

Stellate cells are resident lipid-storing cells of the pancreas and liver that transdifferentiate to
a myofibroblastic state in the context of tissue injury. Beyond having roles in tissue …

Nonalcoholic fatty liver disease (NAFLD) is prevalent in the majority of individuals with
obesity, but in a subset of these individuals, it progresses to nonalcoholic steatohepatitis …

Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it
can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer …

Liver fibrosis and hepatocellular carcinoma (HCC) have been worldwide threats nowadays.
Liver fibrosis is reversible in early stages but will develop precancerosis of HCC in cirrhotic …

Activation of hepatic stellate cell (HSC) involves the transition from a quiescent to a
proliferative, migratory, and fibrogenic phenotype (ie, myofibroblast), which is characteristic …