Dysfunctional reactive oxygen species (ROS) signaling is considered an important disease
mechanism. Therapeutically, non-selective scavenging of ROS by antioxidants, however …

Reactive oxygen species (ROS), formed by the partial reduction of oxygen, were for a long
time considered to be a byproduct of cellular metabolism. Since, increase in cellular levels of …

Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz
Disse, the structure and functions of the space of Disse, a thin perisinusoidal area between …

Activation of hepatic stellate cells (HSC) is a hallmark event in liver fibrosis. Accumulation of
reactive oxygen species (ROS) serves as a driving force for HSC activation. The regulatory …

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are key producer
of reactive oxygen species in liver cells. Hepatic stellate cells (HSCs) and Kupffer cells (KCs) …

Hepatic fibrosis is marked by activation of hepatic stellate cells (HSCs). Cholestatic injury
precedes liver fibrosis, and cholangiocytes interact with HSCs promoting fibrosis. Mast cells …

Liver fibrosis, which is the outcome of wound-healing response to chronic liver damage,
represents an unmet clinical need. This study evaluated the anti-fibrotic and anti …

The lipid-storage hepatic stellate cells (HSC) play as pivotal role in liver fibrosis being able
to trans-differentiate into myofibroblasts in response to various pro-fibrogenic stimuli. In the …

Though ursodeoxycholic acid (UDCA) remains the baseline treatment for most cholestatic
liver diseases, UDCA treatment leaves approximately one-third of patients with primary …

Hepatic fibrosis is commonly diagnosed in dogs, often as a sequela to chronic hepatitis
(CH). The development of fibrosis is a crucial event in the progression of hepatic disease …