[HTML][HTML] Hepatoprotective effect of methyl ferulic acid against carbon tetrachloride-induced acute liver injury in rats

C Yang, L Li, Z Ma, Y Zhong… - Experimental and …, 2018 - spandidos-publications.com
The present study aimed to investigate the hepatoprotective effects of methyl ferulic acid
(MFA) against oxidative stress and apoptosis in acute liver injury induced by carbon …

Feminization of male mouse liver by persistent growth hormone stimulation: activation of sex-biased transcriptional networks and dynamic changes in chromatin states

D Lau-Corona, A Suvorov… - Molecular and cellular …, 2017 - Am Soc Microbiol
Sex-dependent pituitary growth hormone (GH) secretory profiles—pulsatile in males and
persistent in females—regulate the sex-biased, STAT5-dependent expression of hundreds …

The chromatin remodeler Brg1 integrates ROS production and endothelial-mesenchymal transition to promote liver fibrosis in mice

Z Li, B Chen, W Dong, M Kong, Y Shao… - Frontiers in cell and …, 2019 - frontiersin.org
Trans-differentiation of endothelial cells to myofibroblast contributes to liver fibrosis.
Reactive oxygen species (ROS) plays a key role in endothelial-mesenchymal transition …

Inhibition of Nox4‐dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal‐mediated protumorigenic interactions

N Sampson, E Brunner, A Weber… - … journal of cancer, 2018 - Wiley Online Library
Carcinoma‐associated fibroblasts (CAFs) play a key onco‐supportive role during prostate
cancer (PCa) development and progression. We previously reported that the reactive …

Targeting hepatic stellate cells for the treatment of liver fibrosis by natural products: is it the dawning of a new era?

YT Chan, N Wang, HY Tan, S Li, Y Feng - Frontiers in pharmacology, 2020 - frontiersin.org
Liver fibrosis is a progressive liver damage condition that is worth studying widely. It is
important to target and alleviate the disease at an early stage before turning into later …

Pathophysiology of gadolinium-associated systemic fibrosis

B Wagner, V Drel, Y Gorin - American Journal of Physiology …, 2016 - journals.physiology.org
Systemic fibrosis from gadolinium-based magnetic resonance imaging contrast is a scourge
for the afflicted. Although gadolinium-associated systemic fibrosis is a rare condition, the …

Ginsenoside Rg1 ameliorates aging‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice

Y Li, D Zhang, L Li, Y Han, X Dong… - Molecular …, 2021 - spandidos-publications.com
Aging is often accompanied by liver injury and fibrosis, eventually leading to the decline in
liver function. However, the mechanism of aging‑induced liver injury and fibrosis is still not …

Microengineered cultures containing human hepatic stellate cells and hepatocytes for drug development

MD Davidson, DA Kukla, SR Khetani - Integrative Biology, 2017 - academic.oup.com
In non-alcoholic steatohepatitis (NASH), hepatic stellate cells (HSC) differentiate into
myofibroblast-like cells that cause fibrosis, which predisposes patients to cirrhosis and …

Signaling nodes associated with endoplasmic reticulum stress during NAFLD progression

JH Koo, CY Han - Biomolecules, 2021 - mdpi.com
Excess and sustained endoplasmic reticulum (ER) stress, paired with a failure of initial
adaptive responses, acts as a critical trigger of nonalcoholic fatty liver disease (NAFLD) …

Combination therapy based on targeted nano drug co-delivery systems for liver fibrosis treatment: A review

L Zhou, Y Li, Q Liang, J Liu, Y Liu - Journal of Drug Targeting, 2022 - Taylor & Francis
Liver fibrosis is the hallmark of liver disease and occurs prior to the stages of cirrhosis and
hepatocellular carcinoma. Any type of liver damage or inflammation can result in fibrosis …