Hepatic fibrosis is a disease characterized by excessive deposition of extracellular matrix
(ECM) in the liver. Activation of hepatic stellate cells (HSCs) is responsible for most of ECM …

Biglycan, a ubiquitous proteoglycan, acts as a danger signal when released from the
extracellular matrix. As such, biglycan triggers the synthesis and maturation of interleukin-1β …

Objective Chronic liver diseases often involve metabolic damage to the skeletal system. The
underlying mechanism of bone loss in chronic liver diseases remains unclear, and …

Nonalcoholic fatty liver disease (NAFLD), main cause of liver damage, is inextricably linked
to diabetes. However, there is no specific means to improve the pathology of fatty liver in …

This study focused on the relationship between extracellular-regulated kinase (ERK) and
obesity-induced increases in neuropathic pain. We fed rats a high-fat diet to establish the …

Background Studies have shown that both NOX4 and RhoA play essential roles in fibrosis
and that they regulate each other. In lung fibrosis, NOX4/ROS is located upstream of the …

NADPH oxidase (Nox) variants Nox1, Nox2 and Nox4 are implicated in the progression of
liver fibrosis. However, the role of Nox5 is not yet known, mainly due to the lack of this …

Fibrosis is the formation of excessive fibrous connective tissue in an organ or tissue, which
occurs in reparative process or in response to inflammation. Fibrotic diseases are …

Abstract Treatment of neuropathic pain remains challenging as the etiology is
heterogeneous and pathomechanisms are incompletely understood. One possible …

Liver sinusoids serve as the first line of defense against extrahepatic stimuli from the
intestinal tract. Hepatic stellate cells (HSCs) are pericytes residing in the perisinusoidal …