CRISPR/Cas9 therapeutics: progress and prospects

T Li, Y Yang, H Qi, W Cui, L Zhang, X Fu, X He… - … and Targeted Therapy, 2023 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

Neutrophils in chronic inflammatory diseases

A Herrero-Cervera, O Soehnlein… - Cellular & molecular …, 2022 - nature.com
Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

P Kong, ZY Cui, XF Huang, DD Zhang… - Signal transduction and …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

The role of inflammation in cardiovascular disease

MY Henein, S Vancheri, G Longo… - International journal of …, 2022 - mdpi.com
Atherosclerosis is a chronic inflammatory disease, in which the immune system has a
prominent role in its development and progression. Inflammation-induced endothelial …

The biology of TREM receptors

M Colonna - Nature Reviews Immunology, 2023 - nature.com
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Z Luo, M Tian, G Yang, Q Tan, Y Chen, G Li… - Signal transduction and …, 2022 - nature.com
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

[HTML][HTML] The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease

G Oliver, J Kipnis, GJ Randolph, NL Harvey - Cell, 2020 - cell.com
Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

[HTML][HTML] Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

H Yoon, JL Shaw, MC Haigis, A Greka - Molecular cell, 2021 - cell.com
Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

[HTML][HTML] Western diet and the immune system: an inflammatory connection

A Christ, M Lauterbach, E Latz - Immunity, 2019 - cell.com
The consumption of Western-type calorically rich diets combined with chronic overnutrition
and a sedentary lifestyle in Western societies evokes a state of chronic metabolic …