Targeting IL-6 trans-signalling: past, present and future prospects

S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

IL-6/STAT3 is a promising therapeutic target for hepatocellular carcinoma

J Xu, H Lin, G Wu, M Zhu, M Li - Frontiers in oncology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …

Suppression of cytokine release syndrome during CAR-T-cell therapy via a subcutaneously injected interleukin-6-adsorbing hydrogel

X Li, N Gong, F Tian, S Zhang, Y Zhang… - Nature Biomedical …, 2023 - nature.com
The infusion of chimaeric antigen receptor (CAR) T cells can trigger the release of life-
threatening supraphysiological levels of pro-inflammatory cytokines. However, uncertainty …

IL-6/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease

J Park, Y Zhao, F Zhang, S Zhang, AC Kwong… - Journal of …, 2023 - Elsevier
Background & Aims A number of genetic polymorphisms have been associated with
susceptibility to or protection against non-alcoholic fatty liver disease (NAFLD), but the …

Hepatocytes: a key role in liver inflammation

J Gong, W Tu, J Liu, D Tian - Frontiers in Immunology, 2023 - frontiersin.org
Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular
functions including carbohydrate, lipid and protein metabolism, detoxification and immune …

The gut-brain axis in inflammatory bowel disease—current and future perspectives

C Günther, V Rothhammer, M Karow… - International Journal of …, 2021 - mdpi.com
The gut–brain axis is a bidirectional communication system driven by neural, hormonal,
metabolic, immunological, and microbial signals. Signaling events from the gut can …

Interleukin-6 is a circulating prognostic biomarker for hepatocellular carcinoma patients treated with combined immunotherapy

Y Myojin, T Kodama, R Sakamori, K Maesaka… - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is a major cause of cancer death
worldwide. Due to its high recurrence rate, many HCC patients progress to an advanced …

[HTML][HTML] Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis

L Wang, L Zhu, C Liang, X Huang, Z Liu, J Huo… - Journal of …, 2023 - Elsevier
Background & Aims RNA N 6-methyladenosine (m 6 A) reader protein YTHDF1 has been
implicated in cancer; however, its role in hepatocellular carcinoma (HCC), especially in non …

[HTML][HTML] Nuclear translocation of thioredoxin-1 promotes colorectal cancer development via modulation of the IL-6/STAT3 signaling axis through interaction with …

A Wu, D Fang, Y Liu, X Shi, Z Zhong, B Zhou, L Ye… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Thioredoxin 1 (Trx-1) is a small redox protein predominantly localized in the
cytoplasm. Its expression is increased in several cancers, including colorectal cancer (CRC) …

[HTML][HTML] Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease

T Schumertl, J Lokau, S Rose-John… - Biochimica et Biophysica …, 2022 - Elsevier
The pleiotropic cytokine interleukin-6 (IL-6) is involved in numerous physiological and
pathophysiological functions that include development, immune cell differentiation …