Targeting IL-6 trans-signalling: past, present and future prospects
S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
IL-6/STAT3 is a promising therapeutic target for hepatocellular carcinoma
J Xu, H Lin, G Wu, M Zhu, M Li - Frontiers in oncology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …
Suppression of cytokine release syndrome during CAR-T-cell therapy via a subcutaneously injected interleukin-6-adsorbing hydrogel
The infusion of chimaeric antigen receptor (CAR) T cells can trigger the release of life-
threatening supraphysiological levels of pro-inflammatory cytokines. However, uncertainty …
threatening supraphysiological levels of pro-inflammatory cytokines. However, uncertainty …
IL-6/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease
Background & Aims A number of genetic polymorphisms have been associated with
susceptibility to or protection against non-alcoholic fatty liver disease (NAFLD), but the …
susceptibility to or protection against non-alcoholic fatty liver disease (NAFLD), but the …
Hepatocytes: a key role in liver inflammation
J Gong, W Tu, J Liu, D Tian - Frontiers in Immunology, 2023 - frontiersin.org
Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular
functions including carbohydrate, lipid and protein metabolism, detoxification and immune …
functions including carbohydrate, lipid and protein metabolism, detoxification and immune …
The gut-brain axis in inflammatory bowel disease—current and future perspectives
The gut–brain axis is a bidirectional communication system driven by neural, hormonal,
metabolic, immunological, and microbial signals. Signaling events from the gut can …
metabolic, immunological, and microbial signals. Signaling events from the gut can …
Interleukin-6 is a circulating prognostic biomarker for hepatocellular carcinoma patients treated with combined immunotherapy
Y Myojin, T Kodama, R Sakamori, K Maesaka… - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is a major cause of cancer death
worldwide. Due to its high recurrence rate, many HCC patients progress to an advanced …
worldwide. Due to its high recurrence rate, many HCC patients progress to an advanced …
[HTML][HTML] Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis
L Wang, L Zhu, C Liang, X Huang, Z Liu, J Huo… - Journal of …, 2023 - Elsevier
Background & Aims RNA N 6-methyladenosine (m 6 A) reader protein YTHDF1 has been
implicated in cancer; however, its role in hepatocellular carcinoma (HCC), especially in non …
implicated in cancer; however, its role in hepatocellular carcinoma (HCC), especially in non …
[HTML][HTML] Nuclear translocation of thioredoxin-1 promotes colorectal cancer development via modulation of the IL-6/STAT3 signaling axis through interaction with …
A Wu, D Fang, Y Liu, X Shi, Z Zhong, B Zhou, L Ye… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Thioredoxin 1 (Trx-1) is a small redox protein predominantly localized in the
cytoplasm. Its expression is increased in several cancers, including colorectal cancer (CRC) …
cytoplasm. Its expression is increased in several cancers, including colorectal cancer (CRC) …
[HTML][HTML] Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease
T Schumertl, J Lokau, S Rose-John… - Biochimica et Biophysica …, 2022 - Elsevier
The pleiotropic cytokine interleukin-6 (IL-6) is involved in numerous physiological and
pathophysiological functions that include development, immune cell differentiation …
pathophysiological functions that include development, immune cell differentiation …