Calreticulin: Endoplasmic reticulum Ca2+ gatekeeper
M Michalak - Journal of Cellular and Molecular Medicine, 2024 - Wiley Online Library
Endoplasmic reticulum (ER) luminal Ca2+ is vital for the function of the ER and regulates
many cellular processes. Calreticulin is a highly conserved, ER‐resident Ca2+ binding …
many cellular processes. Calreticulin is a highly conserved, ER‐resident Ca2+ binding …
Endoplasmic reticulum homeostasis—From molecules to organisms: Report on the 14th International Calreticulin Workshop, Saint Malo, France
K Bakambamba, F Di Modugno… - Journal of Cellular …, 2024 - Wiley Online Library
Abstract The Calreticulin Workshop, initiated in 1994 by Marek Michalak in Banff (Alberta,
Canada), was first organized to be an informal scientific meeting attended by researchers …
Canada), was first organized to be an informal scientific meeting attended by researchers …
Structural modeling of cytokine-receptor-JAK2 signaling complexes using AlphaFold Multimer
Homodimeric class 1 cytokine receptors include the erythropoietin (EPOR), thrombopoietin
(TPOR), granulocyte colony-stimulating factor 3 (CSF3R), growth hormone (GHR), and …
(TPOR), granulocyte colony-stimulating factor 3 (CSF3R), growth hormone (GHR), and …
[HTML][HTML] Leukemic conversion involving RAS mutations of type 1 CALR-mutated primary myelofibrosis in a patient treated for HCV cirrhosis: a case report
P Gurban, C Mambet, A Botezatu, LG Necula… - Frontiers in …, 2023 - frontiersin.org
Somatic frameshift mutations in exon 9 of calreticulin (CALR) gene are recognized as
disease drivers in primary myelofibrosis (PMF), one of the three classical Philadelphia …
disease drivers in primary myelofibrosis (PMF), one of the three classical Philadelphia …
[PDF][PDF] Molecular pathogenesis of myeloproliferative neoplasms: Where do we stand in 2023?
V Havelange, SN Constantinescu - American journal of …, 2023 - dial.uclouvain.be
Molecular pathogenesis of myeloproliferative neoplasms: Where do we stand in 2023? Page
1 COMMENTARY Molecular pathogenesis of myeloproliferative neoplasms: Where do we …
1 COMMENTARY Molecular pathogenesis of myeloproliferative neoplasms: Where do we …
Antibody targeting of mutant calreticulin in myeloproliferative neoplasms
F Kramer, A Mullally - Journal of Cellular and Molecular …, 2024 - Wiley Online Library
Mutations in calreticulin are one of the key disease‐initiating mutations in myeloproliferative
neoplasms (MPN). In MPN, mutant calreticulin translates with a novel C‐terminus that leads …
neoplasms (MPN). In MPN, mutant calreticulin translates with a novel C‐terminus that leads …
Lysosomal Degradation Pathways Target Mutant Calreticulin and the Thrombopoietin Receptor in Myeloproliferative Neoplasms
A Kaur, A Venkatesan, M Kandarpa, M Talpaz… - bioRxiv, 2023 - biorxiv.org
Somatic mutants of calreticulin (CRT) drive myeloproliferative neoplasms (MPNs) via
binding to the thrombopoietin receptor (MPL) and aberrant activation of the JAK/STAT …
binding to the thrombopoietin receptor (MPL) and aberrant activation of the JAK/STAT …