Background The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the
brain is crucial for maintaining normal physiological functions. Studies have shown that …

The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, with no
cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) …

Alzheimer's disease (AD) is considered the sixth leading cause of death in elderly patients
and is characterized by progressive neuronal degeneration and impairment in memory …

Over the past thirty years, researchers have highlighted the role played by a class of proteins
or polypeptides that forms pathogenic amyloid aggregates in vivo, including i) the amyloid …

Amyloid-β (Aβ) aggregation intermediates, including oligomers and protofibrils (PFs), have
attracted attention as neurotoxic aggregates in Alzheimer's disease. However, due to the …

A major hallmark of Alzheimer's disease is the misfolding and aggregation of the amyloid-β
peptide (Aβ). While early research pointed towards large fibrillar-and plaque-like aggregates …

Aβ, IAPP, α-synuclein, and prion proteins belong to the amyloidogenic intrinsically
disordered proteins' family; indeed, they lack well defined secondary and tertiary structures …

As a longstanding problem, Alzheimer's disease (AD) has stymied researchers in the
medical field with its increasing incidence and enormous treatment difficulty. Silymarin has …

In several neurodegenerative diseases, cell toxicity can emerge from damage produced by
amyloid aggregates to lipid membranes. The details accounting for this damage are poorly …