Pharmacotherapy of type 2 diabetes: An update and future directions
A DeMarsilis, N Reddy, C Boutari, A Filippaios… - Metabolism, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and
social impact for which multiple conventional and novel pharmacotherapies are currently …
social impact for which multiple conventional and novel pharmacotherapies are currently …
[HTML][HTML] Hepatokines and non-alcoholic fatty liver disease: linking liver pathophysiology to metabolism
The liver plays a key role in maintaining energy homeostasis by sensing and responding to
changes in nutrient status under various metabolic conditions. Recently highlighted as a …
changes in nutrient status under various metabolic conditions. Recently highlighted as a …
The roles of FLOT1 in human diseases
Z Zhan, M Ye, X Jin - Molecular Medicine Reports, 2023 - spandidos-publications.com
FLOT1, a scaffold protein of lipid rafts, is involved in several biological processes, including
lipid raft protein‑dependent or clathrin‑independent endocytosis, and the formation of …
lipid raft protein‑dependent or clathrin‑independent endocytosis, and the formation of …
Hepatokines: Unveiling the molecular and cellular mechanisms connecting hepatic tissue to insulin resistance and inflammation
X Miao, A Alidadipour, V Saed, F Sayyadi, Y Jadidi… - Acta Diabetologica, 2024 - Springer
Insulin resistance arising from Non-Alcoholic Fatty Liver Disease (NAFLD) stands as a
prevalent global ailment, a manifestation within societies stemming from individuals' …
prevalent global ailment, a manifestation within societies stemming from individuals' …
Construction and functional evaluation of oral long-acting insulin hydrogel microparticles based on physical and chemical double crosslinking
SQ Chen, QY Miao, Y Liu, Q Xiao, YK Lin… - International Journal of …, 2023 - Elsevier
The objective of this study was to enhance the convenience and effectiveness of diabetes
treatment by developing hydrogel microparticles as an oral insulin delivery system, aiming to …
treatment by developing hydrogel microparticles as an oral insulin delivery system, aiming to …
[HTML][HTML] Betatrophin and insulin resistance
Q Guo, S Cao, X Wang - Metabolites, 2022 - mdpi.com
Betatrophin (angiopoietin-like protein 8 (ANGPTL8)) is a hormone that was recently
discovered in the human liver. Multiple homologous sequences have been detected in …
discovered in the human liver. Multiple homologous sequences have been detected in …
Increased hepatic gluconeogenesis and type 2 diabetes mellitus
Abnormally increased hepatic gluconeogenesis is a significant contributor to hyperglycemia
in the fasting state in patients with type 2 diabetes mellitus (T2DM) due to insulin resistance …
in the fasting state in patients with type 2 diabetes mellitus (T2DM) due to insulin resistance …
Effects of chitosan guanidine on blood glucose regulation and gut microbiota in T2DM
Y Liu, Q Miao, Y Liu, M Jiang - International Journal of Biological …, 2024 - Elsevier
Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia. Type
2 diabetes mellitus (T2DM) represents approximately 90% of all DM cases and is primarily …
2 diabetes mellitus (T2DM) represents approximately 90% of all DM cases and is primarily …
[HTML][HTML] Multi-omics reveal disturbance of glucose homeostasis in pregnant rats exposed to short-chain perfluorobutanesulfonic acid
G Yu, T Luo, Y Liu, X Huo, C Mo, B Huang, Y Li… - Ecotoxicology and …, 2024 - Elsevier
Perfluorobutanesulfonic acid (PFBS), a short-chain alternative to perfluorooctanesulfonic
acid (PFOS), is widely used in various products and is increasingly present in environmental …
acid (PFOS), is widely used in various products and is increasingly present in environmental …
[HTML][HTML] A genome-wide landscape of mRNAs, lncRNAs, circRNAs and miRNAs during intramuscular adipogenesis in cattle
X Yang, X Ma, C Mei, L Zan - BMC genomics, 2022 - Springer
Background Intramuscular preadipocyte differentiation plays a critical role in bovine
intramuscular fat (IMF) deposition. However, the roles of different RNAs, including mRNAs …
intramuscular fat (IMF) deposition. However, the roles of different RNAs, including mRNAs …