Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …

Histone deacetylases, as a new class of anticancer targets, could maintain homeostasis by
catalyzing histone deacetylation and play important roles in regulating the expression of …

Exploring multi-targeting chemotherapeutants with advantages over single-targeting agents
and drug combinations is of great significance in drug discovery. Herein, we employed …

Despite the encouraging clinical progress of chemotherapeutic agents in cancer treatment,
innovation and development of new effective anticancer candidates still represents a …

Abstract Background Cancer stem cells (CSCs) are strongly associated with high
tumourigenicity, chemotherapy or radiotherapy resistance, and metastasis and recurrence …

Due to the multimodal character of cancer, inhibition of two targets simultaneously by a
single molecule is a beneficial and effective approach against cancer. Histone deacetylase …

Objective. Glioblastoma is one of the most common malignant tumors in the brain, and these
glioblastoma patients have very poor prognosis. Ferroptosis is involved in the progression of …

Prostate cancer (PCa) is among the most commonly diagnosed solid cancers in male adults.
However, most anti-angiogenic therapies and immunotherapies fail to achieve durable …

Abstract Introduction Natural products (NPs) play a crucial role in the development of
therapeutic drugs. However, it is still highly challenging to identify the targets of NPs …

It is a well-known phenomenon that natural products can serve as powerful drug leads to
generate new molecular entities with novel therapeutic utility. Evodiamine (Evo), a major …