[HTML][HTML] A review on applications of computational methods in drug screening and design
Drug development is one of the most significant processes in the pharmaceutical industry.
Various computational methods have dramatically reduced the time and cost of drug …
Various computational methods have dramatically reduced the time and cost of drug …
Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy
S Marchiano, K Nakamura, H Reinecke, L Neidig… - Cell Stem Cell, 2023 - cell.com
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer a promising cell-
based therapy for myocardial infarction. However, the presence of transitory ventricular …
based therapy for myocardial infarction. However, the presence of transitory ventricular …
Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation
Background: Small-conductance Ca2+-activated K+ (SK)–channel inhibitors have
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
[HTML][HTML] Modeling cardiac disease mechanisms using induced pluripotent stem cell-derived cardiomyocytes: progress, promises and challenges
Cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood
vessels. Despite progress in clinical research and therapy, CVDs still represent the leading …
vessels. Despite progress in clinical research and therapy, CVDs still represent the leading …
[HTML][HTML] Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly
used for personalised medicine and preclinical cardiotoxicity testing. Reports on hiPSC-CM …
used for personalised medicine and preclinical cardiotoxicity testing. Reports on hiPSC-CM …
[HTML][HTML] All-optical electrophysiology refines populations of in silico human iPSC-CMs for drug evaluation
High-throughput in vitro drug assays have been impacted by recent advances in human
induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) technology and by contact …
induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) technology and by contact …
[HTML][HTML] The simplified Kirchhoff network model (SKNM): a cell-based reaction–diffusion model of excitable tissue
Cell-based models of excitable tissues offer the advantage of cell-level precision, which
cannot be achieved using traditional homogenized electrophysiological models. However …
cannot be achieved using traditional homogenized electrophysiological models. However …
Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling
L Guarina, AN Moghbel… - Journal of General …, 2022 - rupress.org
Each heartbeat begins with the generation of an action potential in pacemaking cells in the
sinoatrial node. This signal triggers contraction of cardiac muscle through a process termed …
sinoatrial node. This signal triggers contraction of cardiac muscle through a process termed …
Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications
Animal experimentation is key in the evaluation of cardiac efficacy and safety of novel
therapeutic compounds. However, interspecies differences in the mechanisms regulating …
therapeutic compounds. However, interspecies differences in the mechanisms regulating …