Bilirubin has several physiological functions, both beneficial and harmful. In addition to
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …

Recent research on bilirubin, a historically well-known waste product of heme catabolism,
suggests an entirely new function as a metabolic hormone that drives gene transcription by …

There is strong evidence that serum free bilirubin concentration has significant effects on
morbidity and mortality in the most significant health conditions of our times, including …

Stroke prognosis is negatively associated with an elevation of serum bilirubin, but how
bilirubin worsens outcomes remains mysterious. We report that post-, but not pre-, stroke …

Bilirubin (BR) is the final product of haem catabolism. Disruptions along BR
metabolic/transport pathways resulting from inherited disorders can increase plasma BR …

Background Ischemia/reperfusion (I/R) injury causes overproduction of reactive oxygen
species, which are the major culprits of oxidative stress that leads to inflammation …

Thromboangiitis obliterans (TAO) or Buerger's disease is a segmental inflammatory,
thrombotic occlusive peripheral vascular disease with unknown aetiology that usually …

Tuberculosis (TB) is still one of the top 10 causes of death in low and lower-middle income
countries [1]. TB's long and complex treatment, side-effects, and development of resistant …

Mitochondrial cardiomyopathies are fatal diseases, with no effective treatment. Alterations of
heart mitochondrial function activate the mitochondrial integrated stress response (ISR mt), a …

Among antioxidants in the human body, bilirubin has been recognized over the past 20
years to afford protection against different chronic conditions, including inflammation and …