Mechanisms of tumor escape from immune system: role of mesenchymal stromal cells

A Poggi, A Musso, I Dapino, MR Zocchi - Immunology letters, 2014 - Elsevier
Tumor microenvironment represents the site where the tumor tries to survive and escape
from immune system-mediated recognition. Indeed, to proliferate tumor cells can divert the …

Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2), a complex target for colorectal cancer prevention and therapy

R Benelli, R Venè, N Ferrari - Translational Research, 2018 - Elsevier
A plentiful literature has linked colorectal cancer (CRC) to inflammation and prostaglandin-
endoperoxide synthase (PTGS) 2 expression. Accordingly, several nonsteroidal …

Novel phenolic compounds as potential dual EGFR and COX-2 inhibitors: Design, semisynthesis, in vitro biological evaluation and in silico Insights

MA Abdelgawad, A Musa, AH Almalki… - Drug design …, 2021 - Taylor & Francis
Introduction Epidermal growth factor receptor (EGFR) inhibition is an imperative therapeutic
approach targeting various types of cancer including colorectal, lung, breast, and pancreatic …

EGFR signaling patterns are regulated by its different ligands

SL Jeppe Knudsen, AS Wai Mac, L Henriksen… - Growth …, 2014 - Taylor & Francis
EGF receptor (EGFR) and its signaling have been investigated for many years, but how its
different ligands regulate signaling has not been thoroughly explored. When investigating …

Oxidative stress‐induced circHBEGF promotes extracellular matrix production via regulating miR‐646/EGFR in human trabecular meshwork cells

W Shen, C Wang, B Huang - Oxidative medicine and cellular …, 2020 - Wiley Online Library
Primary open‐angle glaucoma (POAG), a leading cause of irreversible vision loss, presents
with increased prevalence and a higher degree of clinical severity in the world. Growing …

Endostatin stimulates proliferation and migration of myofibroblasts isolated from myocardial infarction model rats

A Sugiyama, Y Hirano, M Okada… - International Journal of …, 2018 - mdpi.com
Myofibroblasts contribute to the healing of infarcted areas after myocardial infarction through
proliferation, migration, and production of extracellular matrix (ECM). Expression of …

Targeting the epidermal growth factor receptor can counteract the inhibition of natural killer cell function exerted by colorectal tumor-associated fibroblasts

D Costa, R Venè, R Benelli, E Romairone… - Frontiers in …, 2018 - frontiersin.org
Mesenchymal stromal cells (MSC) present in the tumor microenvironment [usually named
tumor-associated fibroblasts (TAF)] can exert immunosuppressive effects on T and natural …

Dracohodin perochlorate stimulates fibroblast proliferation via EGFR activation and downstream ERK/CREB and PI3K/Akt/mTOR pathways in vitro

L Liu, X Jiang, W Yu - Evidence‐Based Complementary and …, 2019 - Wiley Online Library
In recent years, an increasing number of natural plant extracts have been determined to be
potential drugs for various illnesses. In this study, we investigated the effects of dracorhodin …

Insulin receptor tyrosine kinase substrate activates EGFR/ERK signalling pathway and promotes cell proliferation of hepatocellular carcinoma

YP Wang, LY Huang, WM Sun, ZZ Zhang, JZ Fang… - Cancer letters, 2013 - Elsevier
Insulin receptor tyrosine kinase substrate (IRTKS) is closely associated with actin
remodelling and membrane protrusion, but its role in the pathogenesis of malignant …

Priming of colorectal tumor-associated fibroblasts with zoledronic acid conjugated to the anti-epidermal growth factor receptor antibody cetuximab elicits anti-tumor …

JLC Fernandez, R Benelli, D Costa, A Campioli… - Cancers, 2023 - mdpi.com
Simple Summary Different cells present in the tumor microenvironment can deeply influence
both cancer spreading and the success of therapy in solid tumors, including colorectal …