Coumarins and coumarin-related compounds in pharmacotherapy of cancer

E Küpeli Akkol, Y Genç, B Karpuz, E Sobarzo-Sánchez… - Cancers, 2020 - mdpi.com
Cancer is one of the most common causes of disease-related deaths worldwide. Despite the
discovery of many chemotherapeutic drugs that inhibit uncontrolled cell division processes …

Therapeutic effects of coumarins with different substitution patterns

V Flores-Morales, AP Villasana-Ruíz, I Garza-Veloz… - Molecules, 2023 - mdpi.com
The use of derivatives of natural and synthetic origin has gained attention because of their
therapeutic effects against human diseases. Coumarins are one of the most common …

Coumarins as antioxidants

I Kostova, S Bhatia, P Grigorov… - Current medicinal …, 2011 - ingentaconnect.com
Coumarins, a well-known class of naturally occurring compounds, display a remarkable
array of biochemical and pharmacological actions, some of which suggest that certain …

Coumarins: old compounds with novel promising therapeutic perspectives

ME Riveiro, N De Kimpe, A Moglioni… - Current medicinal …, 2010 - ingentaconnect.com
Natural as well as synthetic coumarins have recently drawn much attention due to its broad
pharmacological activities. Many coumarins and their derivatives exert anti-coagulant, anti …

Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis

JM Matés, JA Segura, FJ Alonso, J Márquez - Archives of toxicology, 2008 - Springer
Oxidative stress can be defined as the imbalance between cellular oxidant species
production and antioxidant capability. Reactive oxygen species (ROS) are involved in a …

Pharmacological and nutritional effects of natural coumarins and their structure–activity relationships

JJ Zhu, JG Jiang - Molecular nutrition & food research, 2018 - Wiley Online Library
Coumarins are fused benzene and pyrone ring systems with a wide spectrum of
bioactivities, including antitumor, anti‐inflammation, antiviral, and antibacterial effects. In this …

The structure and pharmacological functions of coumarins and their derivatives

L Wu, X Wang, W Xu, F Farzaneh… - Current medicinal …, 2009 - ingentaconnect.com
Coumarins are of many different structures. They constitute an important class of
pharmacological agents possessing a range of different physiological activities including …

The anticancer properties of dietary polyphenols and its relation with apoptosis

P Fresco, F Borges, MPM Marques… - Current pharmaceutical …, 2010 - ingentaconnect.com
Aberrantly regulated apoptosis is involved in the pathogenesis of several diseases and
defective apoptosis leads to uncontrolled cell proliferation and tumorigenesis. Cancer is an …

Coumarin: a promising scaffold for anticancer agents

M Kaur, S Kohli, S Sandhu, Y Bansal… - Anti-Cancer Agents in …, 2015 - ingentaconnect.com
Coumarin enjoys an important place in drug discovery process due to its presence in
diversity of biologically active compounds. Many compounds of plant origin are derivatives …

Coumarins scaffolds as COX inhibitors

HM Revankar, SNA Bukhari, GB Kumar, HL Qin - Bioorganic Chemistry, 2017 - Elsevier
The discovery of COX enzymes has led to a better understanding of inflammation and its
related biological pathways. Apart from being related to inflammation and pain, it has also …