Exosomes: key players in cancer and potential therapeutic strategy

J Dai, Y Su, S Zhong, L Cong, B Liu, J Yang… - Signal transduction and …, 2020 - nature.com
Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in
intercellular communication. The components of exosomes, including proteins, DNA, mRNA …

[HTML][HTML] Role of lncRNA LUCAT1 in cancer

C Xing, S Sun, ZQ Yue, F Bai - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Long non-coding RNAs (lncRNAs) are RNA molecules with a transcript length of more than
200 nt and lack a protein-coding ability. They regulate gene expression by interacting with …

[HTML][HTML] Drug resistance and combating drug resistance in cancer

X Wang, H Zhang, X Chen - Cancer drug resistance, 2019 - ncbi.nlm.nih.gov
Cancer is the second leading cause of death in the US. Current major treatments for cancer
management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy …

Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches

TB Emran, A Shahriar, AR Mahmud, T Rahman… - Frontiers in …, 2022 - frontiersin.org
Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …

Long noncoding RNA in cancer: wiring signaling circuitry

C Lin, L Yang - Trends in cell biology, 2018 - cell.com
Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the
human genome, may hold missing drivers of cancer and have gained attention recently as a …

Role of non-coding RNAs and RNA modifiers in cancer therapy resistance

X Zhang, K Xie, H Zhou, Y Wu, C Li, Y Liu, Z Liu, Q Xu… - Molecular cancer, 2020 - Springer
As the standard treatments for cancer, chemotherapy and radiotherapy have been widely
applied to clinical practice worldwide. However, the resistance to cancer therapies is a major …

The roles of exosomal miRNAs and lncRNAs in lung diseases

Y Li, Z Yin, J Fan, S Zhang, W Yang - Signal transduction and targeted …, 2019 - nature.com
An increasing number of studies have reported that exosomes released from various cells
can serve as mediators of information exchange between different cells. With further …

LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by sunppressing miR‐184 expression

Z Fang, J Zhao, W Xie, Q Sun, H Wang… - Cancer …, 2017 - Wiley Online Library
Chemotherapy resistance has become the main obstacle for the effective treatment of
human cancers. Long non‐coding RNA urothelial cancer associated 1 (UCA 1) is generally …

The emerging role of lncRNAs in the regulation of cancer stem cells

R Castro-Oropeza, J Melendez-Zajgla, V Maldonado… - Cellular Oncology, 2018 - Springer
Background Tumors contain a functional subpopulation of cells that exhibit stem cell
properties. These cells, named cancer stem cells (CSCs), play significant roles in the …

The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells

CPR Xavier, DC Belisario, R Rebelo, YG Assaraf… - Drug Resistance …, 2022 - Elsevier
Drug resistance remains a major hurdle to successful cancer treatment, being accountable
for approximately 90% of cancer-related deaths. In the past years, increasing attention has …