Targeting cancer-promoting inflammation—have anti-inflammatory therapies come of age?

J Hou, M Karin, B Sun - Nature reviews Clinical oncology, 2021 - nature.com
The immune system has crucial roles in cancer development and treatment. Whereas
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …

Targeting inflammation as cancer therapy

M Wang, S Chen, X He, Y Yuan, X Wei - Journal of Hematology & …, 2024 - Springer
Inflammation has accompanied human beings since the emergence of wounds and
infections. In the past decades, numerous efforts have been undertaken to explore the …

[PDF][PDF] The inflammatory profile of the tumor microenvironment, orchestrated by cyclooxygenase-2, promotes epithelial-mesenchymal transition

F Gómez-Valenzuela, E Escobar… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) corresponds to a complex and dynamic interconnection
between the extracellular matrix and malignant cells and their surrounding stroma …

The efficacy and safety of celecoxib in addition to standard cancer therapy: a systematic review and meta-analysis of randomized controlled trials

SY Ye, JY Li, TH Li, YX Song, JX Sun, XW Chen… - Current …, 2022 - mdpi.com
The purpose of this meta-analysis was to evaluate the efficacy and safety of celecoxib, a
selective cyclooxygenase-2 (COX-2) inhibitor, in addition to standard anticancer therapy …

Impact of radiation therapy on healthy tissues

C Chargari, E Rassy, C Helissey, S Achkar… - International review of …, 2023 - Elsevier
Radiation therapy has a fundamental role in the management of cancers. However, despite
a constant improvement in radiotherapy techniques, the issue of radiation-induced side …

Pathological and pharmacological functions of the metabolites of polyunsaturated fatty acids mediated by cyclooxygenases, lipoxygenases, and cytochrome P450s in …

YW Meng, JY Liu - Pharmacology & Therapeutics, 2024 - Elsevier
Oxylipins have garnered increasing attention because they were consistently shown to play
pathological and/or pharmacological roles in the development of multiple cancers. Oxylipins …

Comparison of post-chemoradiotherapy pneumonitis between Asian and non-Asian patients with locally advanced non-small cell lung cancer: a systematic review …

T Liu, S Li, S Ding, J Qiu, C Ren, J Chen, H Wang… - …, 2023 - thelancet.com
Background Pneumonitis is a common complication for patients with locally advanced non-
small cell lung cancer undergoing definitive chemoradiotherapy (CRT). It remains unclear …

Metabolic rewiring in radiation oncology toward improving the therapeutic ratio

MW Van Gisbergen, E Zwilling, LJ Dubois - Frontiers in oncology, 2021 - frontiersin.org
To meet the anabolic demands of the proliferative potential of tumor cells, malignant cells
tend to rewire their metabolic pathways. Although different types of malignant cells share this …

Pneumonitis risk after chemoradiotherapy with and without immunotherapy in patients with locally advanced non-small cell lung cancer: A systematic review and meta …

C Han, J Qiu, L Bai, T Liu, J Chen, H Wang… - International Journal of …, 2024 - Elsevier
Purpose Chemoradiotherapy (CRT) combined with immune checkpoint inhibitors (ICIs) is
the standard of care for patients with unresectable and locally advanced non-small cell lung …

Identification of cardiotoxicity related to non-small cell lung cancer (NSCLC) treatments: A systematic review

SHY Chan, Y Khatib, S Webley, D Layton… - Frontiers in …, 2023 - frontiersin.org
Introduction: In the last few decades, there has been a rapid development in cancer
therapies and improved detection strategies, hence the death rates caused by cancer have …