Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …

Acute myocardial infarction (AMI) and the heart failure (HF) that often result remain the
leading causes of death and disability worldwide. As such, new therapeutic targets need to …

In many excitable cells, KATP channels respond to intracellular adenosine nucleotides: ATP
inhibits while ADP activates. We present two structures of the human pancreatic KATP …

The delayed rectifier potassium IKs channel is an important regulator of the duration of the
ventricular action potential. Hundreds of mutations in the genes (KCNQ1 and KCNE1) …

Cardiomyocytes are endowed with a complex repertoire of ion channels, responsible for the
generation of action potentials (APs), travelling waves of electrical excitation, propagating …

Modulation of mitochondrial K channels represents a pharmacological strategy to promote
cardioprotective effects. Isothiocyanates emerge as molecules capable of releasing …

Pulmonary arterial hypertension (PAH) is a rare and severe cardiopulmonary disease
without curative treatments. PAH is a multifactorial disease that involves genetic …

Despite current advances in perioperative care, intraoperative myocardial protection during
cardiac surgery has not kept the same pace. High potassium cardioplegic solutions were …

KATP channels are metabolic sensors for intracellular ATP/ADP ratios, play essential roles
in many physiological processes, and are implicated in a spectrum of pathological …

Cardiac fibrosis is defined as excessive deposition of extracellular matrix (ECM) in
pathological conditions. Cardiac fibroblasts (CFs) activated by injury or inflammation …