DNA Vaccines: Their formulations, engineering and delivery

M Kozak, J Hu - Vaccines, 2024 - mdpi.com
The concept of DNA vaccination was introduced in the early 1990s. Since then,
advancements in the augmentation of the immunogenicity of DNA vaccines have brought …

Navigating the Immune Maze: Pioneering Strategies for Unshackling Cancer Immunotherapy Resistance

L Yao, Q Wang, W Ma - Cancers, 2023 - mdpi.com
Simple Summary Cancer treatments have made remarkable advances with the introduction
of immunotherapy, which recruits the body's immune system to fight cancer. Despite these …

Therapeutically targeting the unique disease landscape of pediatric high-grade gliomas

D Fernando, AU Ahmed, BRG Williams - Frontiers in Oncology, 2024 - frontiersin.org
Pediatric high-grade gliomas (pHGG) are a rare yet devastating malignancy of the central
nervous system's glial support cells, affecting children, adolescents, and young adults …

Expanding the repertoire reveals recurrent, cryptic, and hematopoietic HLA class I minor histocompatibility antigens

KJ Fuchs, M van de Meent, MW Honders, I Khatri… - Blood, 2024 - ashpublications.org
Allogeneic stem cell transplantation (alloSCT) is a curative treatment for hematological
malignancies. After HLA-matched alloSCT, antitumor immunity is caused by donor T cells …

Current Landscape of Cancer Immunotherapy: Harnessing the Immune Arsenal to Overcome Immune Evasion

A Mitra, A Kumar, NP Amdare, R Pathak - Biology, 2024 - mdpi.com
Simple Summary Cancer immune evasion poses a significant challenge in developing
effective cancer treatments. The interplay between the immune system and tumors …

[HTML][HTML] Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture

J Zenga, M Awan, A Frei, J Foeckler, R Kuehn… - Translational …, 2024 - Elsevier
Background Human papillomavirus (HPV)-negative head and neck squamous cell
carcinoma (HNSCC) remains a treatment-resistance disease with limited response to …

The effects of anti-lung cancer in nude mice by a fully human single-chain antibody against associated antigen Ts7TMR between A549 cells and Trichinella spiralis

T Yue, J Wang, F Liu, P Gong, J Li… - Artificial Cells …, 2024 - Taylor & Francis
Lung cancer is a dangerous disease that is lacking in an ideal therapy. Here, we evaluated
the anti-lung cancer effect in nude mice of a fully human single-chain antibody (scFv) …

Targeting Neoantigens in Cancer: Possibilities and Opportunities in Breast Cancer

Z Chaudhry, A Boyadzhyan, K Sasaninia, V Rai - Antibodies, 2024 - mdpi.com
As one of the most prevalent forms of cancer worldwide, breast cancer has garnered
significant attention within the clinical research setting. While traditional treatment employs a …

Immunoengineering via Chimeric Antigen Receptor-T Cell Therapy: Reprogramming Nanodrug Delivery

T Katopodi, S Petanidis, D Anestakis, C Charalampidis… - Pharmaceutics, 2023 - mdpi.com
Following its therapeutic effect in hematological metastasis, chimeric antigen receptor (CAR)
T cell therapy has gained a great deal of attention during the last years. However, the …

Tumor-Infiltrating Lymphocyte and Other Cell Therapies for Metastatic Melanoma

C Los, S Klobuch, JBAG Haanen - The Cancer Journal, 2024 - journals.lww.com
Major progress in prolonging survival of patients with advanced melanoma has been made
in the past decade because of the development and approval of immune checkpoint …