Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …

Background Brain metastasis (BM) is one of the principal causes of mortality for lung cancer
patients. While the molecular events that govern BM of lung cancer remain frustrating …

Human tubulin beta class IVa (TUBB4A) is a member of the β-tubulin family. In most normal
tissues, expression of TUBB4A is little to none, but it is highly expressed in human prostate …

During the evolution into castration or therapy resistance, prostate cancer cells reprogram
the androgen responses to cope with the diminishing level of androgens, and undergo …

Lung cancer is one of the most common malignant diseases globally, composed of non-
small cell lung cancer (NSCLC, 85%) and small cell lung cancer (SCLC, 15%). MicroRNAs …

Epithelial to mesenchymal transition (EMT) is the process whereby a polarized epithelial cell
ceases to maintain cell-cell contacts, loses expression of characteristic epithelial cell …

Abstract Myocardin (MYOCD) promotes Smad3-mediated transforming growth factor-β (TGF-
β) signaling in mouse fibroblast cells. Our previous studies show that TGF-β/SMADs …

Calycosin is one of the main ingredients extracted from the Chinese medical herb, Radix
astragali (RA). It has been shown to inhibit cell proliferation and induce apoptosis in several …

Acetylation of microtubules (MT) confers mechanical stability necessary for numerous
functions including cell cycle and intracellular transport. Although αTAT1 is a major MT …