Because of profound effects observed in carcinogenesis, prostaglandins (PGs),
prostaglandin-endoperoxide synthases, and PG receptors are implicated in cancer …

As a crucial component of brain innate immunity, neuroinflammation initially contributes to
neuronal tissue repair and maintenance. However, chronic inflammatory processes within …

Highlights•Current treatment for glioblastoma fails to provide sufficient therapeutic
outcomes.•Overexpressed cyclooxygenase-2 (COX-2) contributes to the glioblastoma …

Modulation of a specific prostanoid synthase or receptor provides therapeutic alternatives to
nonsteroidal anti-inflammatory drugs (NSAIDs) for treating pathological conditions governed …

Prostaglandin E2 is now widely recognized to play critical roles in brain inflammation and
injury, although the responsible prostaglandin receptors have not been fully identified. We …

Abstract Background Mesenchymal stem cells (MSCs) have demonstrated remarkable
therapeutic promise for acute lung injury (ALI) and its severe form, acute respiratory distress …

Malignant brain tumors and metastases pose significant health problems and cause
substantial morbidity and mortality in children and adults. Based on epidemiological …

As a prominent inflammatory effector of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE
2) mediates brain inflammation and injury in many chronic central nervous system (CNS) …

Grape pomace is the source of bioactive compounds (anthocyanins, flavonols, flavan‐3‐ols,
and stilbenes) which exhibit antiproliferative actions on cell cultures. We have investigated …

In the wake of health disasters associated with the chronic use of cyclooxygenase-2 (COX-2)
inhibitor drugs, it has been widely proposed that modulation of downstream prostanoid …