[HTML][HTML] Macrophages in immunoregulation and therapeutics

S Chen, AFUH Saeed, Q Liu, Q Jiang, H Xu… - … and Targeted Therapy, 2023 - nature.com
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

[HTML][HTML] Immune cell-mediated features of non-alcoholic steatohepatitis

T Huby, EL Gautier - Nature reviews immunology, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations,
starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis …

[HTML][HTML] Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

[HTML][HTML] Non-alcoholic fatty liver disease (NAFLD) pathogenesis and natural products for prevention and treatment

X Guo, X Yin, Z Liu, J Wang - International journal of molecular sciences, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease,
affecting approximately one-quarter of the global population, and has become a world public …

[HTML][HTML] Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

[HTML][HTML] NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications

HQ Ju, JF Lin, T Tian, D Xie, RH Xu - Signal transduction and targeted …, 2020 - nature.com
Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all
organisms, and provides the reducing power for anabolic reactions and redox balance …

[HTML][HTML] Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …

[HTML][HTML] Drug-induced oxidative stress in cancer treatments: Angel or devil?

H Jiang, J Zuo, B Li, R Chen, K Luo, X Xiang, S Lu… - Redox Biology, 2023 - Elsevier
Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

[HTML][HTML] Molecular mechanisms that link oxidative stress, inflammation, and fibrosis in the liver

E Ramos-Tovar, P Muriel - Antioxidants, 2020 - mdpi.com
Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …

PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets

H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …