Each year an estimated 600 000 new leprosy cases are diagnosed worldwide. The
spectrum of the disease varies widely from limited tuberculoid forms to extensive …

There is increasing interest in and understanding of the role of human genetic factors
controlling susceptibility/resistance to infectious diseases. This is of particular importance for …

Background It is generally accepted that genetic factors play a role in susceptibility to both
leprosy per se and leprosy type, but only few studies have tempted to quantify this …

Background The epidemiology of leprosy in rural Egypt is unknown. This prospective
household survey was conducted in a high‐prevalence Egyptian village in order to explore …

Leprosy is the major cause of non-traumatic neuropathy. Herein, we investigated the role of
ninjurin 1, an adhesion molecule involved in nerve regeneration in leprosy. Our results …

The existence of a genetic component in mycobacterial disease susceptibility is no longer in
doubt and the investigations now being conducted aim to determine which genes are …

The region on chromosome 6 encoding the major histocompatibility complex (MHC) is
associated with a number of autoimmune and infectious diseases. Primary susceptibility to …

Familial aggregation, high relative risk to siblings, and segregation analysis, suggest genetic
control of visceral leishmaniasis in Brazil. Class II gene effects in mice, and high circulating …

The contribution of single nucleotide polymorphisms in tumor necrosis factors (TNF) α and β
to autoimmune diseases, and to type 1 diabetes mellitus (T1DM) in particular, is not well …

Considering that variability in immune response genes has been associated with
susceptibility to leprosy and with disease severity, leprosy presents clinicopathological …