The mechanisms of cardiovascular diseases (CVDs) remain incompletely elucidated. Single-
cell RNA sequencing (scRNA-seq) has enabled the profiling of single-cell transcriptomes at …

Fetal growth restriction (FGR), which most commonly results from suboptimal placental
function, substantially increases risks for adverse perinatal and long-term outcomes. The …

Low blood flow through the fetal left heart is often conjectured as an etiology for hypoplastic
left heart syndrome (HLHS). To investigate if a decrease in left heart flow results in growth …

Background The renin‐angiotensin system plays a crucial role in the development of heart
failure, and Ang II (angiotensin II) acts as the critical effector of the renin‐angiotensin system …

Endothelial cells (ECs) line the luminal surface of blood vessels and play a major role in
vascular (patho)-physiology by acting as a barrier, sensing circulating factors and …

BACKGROUND: Arteriovenous fistulae (AVFs) are the preferred vascular access for
hemodialysis in patients with end-stage kidney disease. Chronic kidney disease (CKD) is …

Genome wide association studies for coronary artery disease (CAD) have identified a risk
locus at 11q22. 3. Here, we verify with mechanistic studies that rs2019090 and PDGFD …

Endothelial cells (ECs) are pivotal in maintaining vascular health, regulating hemodynamics,
and modulating inflammatory responses. Nanocarriers hold transformative potential for …

Pulmonary hypertension (PH) is a progressive disease characterised by elevated pulmonary
arterial pressure and right-sided heart failure. While conventional drug therapies, including …

Acute coronary syndrome (ACS) is the most severe form of ischemic heart disease. Although
it is caused by atherosclerotic plaque thrombosis or nonatherosclerotic causes, its …