Background Engineered carbon nanotubes are currently used in many consumer and
industrial products such as paints, sunscreens, cosmetics, toiletries, electronic processes …

Nuclear factor, erythroid‐derived 2, like 2 (NRF2) is a key regulator of antioxidants and
cellular stress responses. The role of NRF2 in pulmonary neoplasia, a diverse disease for …

Carbon nanotubes are commercially-important products of nanotechnology; however, their
low density and small size makes carbon nanotube respiratory exposures likely during their …

Chronic inflammation plays a key tumor-promoting role in lung cancer. Our previous studies
in mice demonstrated that neutrophils are critical mediators of tumor promotion in …

Mouse models can be useful for increasing the understanding of lung tumorigenesis and
assessing the potential of chemopreventive agents. We explored the role of inflammation in …

Background Elevated levels of air pollution are associated with increased risk of lung
cancer. Particulate matter (PM) contains transition metals that may potentiate neoplastic …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental and occupational
toxicants, which are a major human health concern in the US and abroad. Previous research …

With more than 150,000 deaths per year in the US alone, lung cancer has the highest
number of deaths for any cancer. These poor outcomes reflect a lack of treatment for the …

Low molecular weight polycyclic aromatic hydrocarbons (LMW PAHs;< 206.3 g/mol) are
prevalent and ubiquitous environmental contaminants, presenting a human health concern …

Results Higher mRNA expression of TLR1-3 and 5-8 were significantly associated with
increased overall survival (OS) when analyzed individually or as a group in both non-small …