The relationship between inflammation and cancer has been recognized since the 17th
century, 1 and we now know much about the cells, cytokines and physiological processes …

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

Cancer immunotherapy has been predominantly focused on biologically based intervention
strategies. However, recent advances in the understanding of tumour–host interactions at …

While chemotherapy provides useful palliation, advanced lung cancer remains incurable
since those tumors that are initially sensitive to therapy rapidly develop acquired resistance …

Angiogenesis is a multistep, complex and tightly regulated process that is necessary for
tumor growth and metastasis. Based on data of preclinical models, several antiangiogenic …

The most common and leading cause of cancer-related death in men is lung cancer. Despite
the recent advances in chemotherapy, advanced lung cancer still remains incurable. For …

Background The addition of cyclo-oxygenase-2 (COX-2) inhibitors and prolonged constant
infusion (PCI) of gemcitabine to treatment for advanced non-small-cell lung cancer (NSCLC) …

Over the past decade, a multitude of targeted agents have been explored in the treatment of
advanced non–small cell lung cancer (NSCLC). Thus far, two broad classes of agents have …

Abstract Purpose: Cyclooxygenase (COX)-2 up-regulation plays an important role in the
pathogenesis of lung cancer. Selective COX-2 inhibitors have promoted chemosensitivity …

The versatile hitherto unreported 3-[(E)-3-(dimethylamino) acryloyl]-1, 5-diphenyl-1H-
pyrazole-4-carbonitrile (3) was prepared via the reaction of 3-acetyl-1, 5-diphenyl-1H …