The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell
structure and behaviour, affecting cell morphology, proliferation, survival and differentiation …

Rapid progress has been made in the understanding of the molecular interactions that result
in cell adhesion. Many adhesive proteins present in extracellular matrices and in the blood …

Targeted delivery of therapeutic and imaging agents in the vascular compartment represents
a significant hurdle in using nanomedicine for treating hemorrhage, thrombosis, and …

What do cell adhesion, cell migration during embryogenesis, thrombosis, and lymphocyte
help and killing have in common? It has recently become clear that these ostensibly …

Extravascular fibrin deposition is an early and persistent hallmark of inflammatory
responses. Fibrin is generated from plasma-derived fibrinogen, which escapes the …

The αVβ3 integrin receptor plays an important role in human tumor metastasis and tumor-
induced angiogenesis. The in vivo inhibition of this receptor by antibodies or by cyclic …

We describe the isolation, characterization, and sequence of cDNA clones encoding one
subunit of the complex of membrane glycoproteins that forms part of the transmembrane …

Abstract The tripeptide Arg-Gly-Asp (RGD) was originally identified as the sequence within
fibronectin that mediates cell attachment. The RGD motif has now been found in numerous …