The role of biomolecular condensates in protein aggregation
BS Visser, WP Lipiński, E Spruijt - Nature Reviews Chemistry, 2024 - nature.com
There is an increasing amount of evidence that biomolecular condensates are linked to
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …
[HTML][HTML] Insights into Calpain Activation and Rho-ROCK Signaling in Parkinson's Disease and Aging
A Gathings, V Zaman, NL Banik, A Haque - Biomedicines, 2024 - mdpi.com
Parkinson's disease (PD), a progressive neurodegenerative disease, has no cure, and
current therapies are not effective at halting disease progression. The disease affects mid …
current therapies are not effective at halting disease progression. The disease affects mid …
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
The intricate process of α-synuclein aggregation and fibrillization hold pivotal roles in
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …
[HTML][HTML] Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons
S Gima, K Oe, K Nishimura, T Ohgita, H Ito… - Regenerative …, 2024 - Elsevier
Introduction Cell therapeutic clinical trials using fetal mesencephalic tissue provided a proof-
of-concept for regenerative therapy in patients with Parkinson's disease. Postmortem studies …
of-concept for regenerative therapy in patients with Parkinson's disease. Postmortem studies …
Liquid–liquid phase separation of alpha‐synuclein increases the structural variability of fibrils formed during amyloid aggregation
M Ziaunys, D Sulskis, D Veiveris, A Kopustas… - The FEBS …, 2023 - Wiley Online Library
Protein liquid–liquid phase separation (LLPS) is a rapidly emerging field of study on
biomolecular condensate formation. In recent years, this phenomenon has been implicated …
biomolecular condensate formation. In recent years, this phenomenon has been implicated …
Physicochemical mechanisms of aggregation and fibril formation of α-synuclein and apolipoprotein AI
T Ohgita, H Kono, N Namba, H Saito - Biophysics and …, 2024 - jstage.jst.go.jp
Deposition and accumulation of amyloid fibrils is a hallmark of a group of diseases called
amyloidosis and neurodegenerative disorders. Although polypeptides potentially have a …
amyloidosis and neurodegenerative disorders. Although polypeptides potentially have a …
CRISPR Screen for Protein Inclusion Formation Uncovers SRRD as a Novel Regulator of Aggresome Formation and Cellular Proteostasis
KM Sweeney - 2023 - search.proquest.com
A defining feature of human neurodegenerative diseases (NDs) is pathological protein
aggregation. In the related NDs, amyotrophic lateral sclerosis (ALS) and frontotemporal …
aggregation. In the related NDs, amyotrophic lateral sclerosis (ALS) and frontotemporal …