[PDF][PDF] Enhanced safety and efficacy of protease-regulated CAR-T cell receptors

L Labanieh, RG Majzner, D Klysz, E Sotillo, CJ Fisher… - Cell, 2022 - cell.com
Regulatable CAR platforms could circumvent toxicities associated with CAR-T therapy, but
existing systems have shortcomings including leakiness and attenuated activity. Here, we …

Designing dose-finding phase I clinical trials: top 10 questions that should be discussed with your statistician

SM Lee, NA Wages, KA Goodman… - JCO precision …, 2021 - ascopubs.org
In recent years, the landscape in clinical trial development has changed to involve many
molecularly targeted agents, immunotherapies, or radiotherapy, as a single agent or in …

Introduction to Special Issue on 'Statistical Methods for Cancer Immunotherapy'

B Huang, N Ting - Statistics in Biosciences, 2020 - Springer
With decades of progress in medical research and advance in understanding the biology of
cancer microenvironment, clinical development of novel cancer drugs including …