CyTOF-Lec: Single-cell Glycomics Analysis Reveals Glycan Features Defining Cells Differentially Susceptible to HIV

T Ma, M McGregor, LB Giron, G Xie, AF George… - bioRxiv, 2022 - biorxiv.org
High-parameter single-cell phenotyping has enabled in-depth classification and
interrogation of immune cells, but to date has not allowed for glycan characterization. Here …

Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV

T Ma, M McGregor, L Giron, G Xie, AF George… - Elife, 2022 - elifesciences.org
High-parameter single-cell phenotyping has enabled in-depth classification and
interrogation of immune cells, but to date has not allowed for glycan characterization. Here …

[引用][C] Droplet‐Based Glycan and RNA Sequencing for Profiling the Distinct Cellular Glyco‐States in Single Cells (Small Methods 5/2024)

S Keisham, S Saito, S Kowashi, H Tateno - Small Methods, 2024 - Wiley Online Library
In article number 2301338, Tateno and co-workers developed a droplet-based scGR-seq
method to simultaneously profile the glycome and transcriptome of 10 000 cells in a single …

Innate Recognition of HIV-1 Glycans: Implications for Infection, Transmission, and Immunity

AMG van der Aar, SI Gringhuis… - HIV glycans in infection …, 2013 - Springer
Innate immune cells such as dendritic cells (DCs), Langerhans cells (LCs), and
macrophages are equipped with pattern recognition receptors that sense invading …

Sialyl-LewisX glycoantigen is enriched on cells with persistent HIV transcription during therapy

F Colomb, LB Giron, L Kuri-Cervantes, OS Adeniji… - Cell reports, 2020 - cell.com
A comprehensive understanding of the phenotype of persistent HIV-infected cells,
transcriptionally active and/or transcriptionally inactive, is imperative for developing a cure …

Droplet‐Based Glycan and RNA Sequencing for Profiling the Distinct Cellular Glyco‐States in Single Cells

S Keisham, S Saito, S Kowashi, H Tateno - Small Methods, 2024 - Wiley Online Library
Plate‐based single‐cell glycan and RNA sequencing (scGR‐seq) is previously developed to
realize the integrated analysis of glycome and transcriptome in single cells. However, the …

A Unified Atlas of T cell Glycophysiology

FN Izzati, H Choksi, P Giuliana, D Abd-Rabbo… - bioRxiv, 2024 - biorxiv.org
Glycans are emerging as important regulators of T cell function but remain poorly
characterized across the functionally distinct populations that exist in vivo. Here, we couple …

Breaking the glyco-code of HIV persistence and immunopathogenesis

F Colomb, LB Giron, I Trbojevic-Akmacic, G Lauc… - Current HIV/AIDS …, 2019 - Springer
Purpose of review Glycoimmunology is an emerging field focused on understanding how
immune responses are mediated by glycans (carbohydrates) and their interaction with …

Deep learning explains the biology of branched glycans from single-cell sequencing data

R Qin, LK Mahal, D Bojar - Iscience, 2022 - cell.com
Glycosylation is ubiquitous and often dysregulated in disease. However, the regulation and
functional significance of various types of glycosylation at cellular levels is hard to unravel …

HIV Glycomics and Glycoproteomics

C Bonomelli, M Crispin, CN Scanlan… - HIV glycans in infection …, 2014 - Springer
The HIV-1 surface glycoprotein, gp120, is made of a rapidly mutating protein core, encoded
by the viral genome, and an extensive carbohydrate shield which is synthesized by the host …