Fibrous dysplasia of bone is a genetic, non-inheritable disease, characterized by bone pain,
bone deformities and fracture, involving one or several bones. It is caused by mis-sense …

Fibrous dysplasia is an uncommon mosaic disorder in which bone is replaced by structurally
unsound fibro-osseous tissue. It is caused by the sporadic post-zygotic activating mutations …

THE MCCUNE-ALBRIGHT SYNDROME is characterized by sex-ual precocity, large and
rough-bordered café-au-lait spots, and polyostotic fibrous dysplasia due to the mosaic …

Fibrous dysplasia (FD) of bone is an uncommon disease caused by sporadic, congenital
mutations in the cAMP regulating protein, Gsα. It is an example of somatic mosaicism in …

Fibrous dysplasia (FD) is an uncommon and debilitating skeletal disorder resulting in
fractures, deformity, functional impairment, and pain. It arises from post-zygotic somatic …

McCune‐Albright syndrome (MAS) is a rare bone disorder characterized by fibrous
dysplasia (FD), endocrinopathies, and café‐au‐lait patches. FD patients have been shown …

Fibrous dysplasia (FD) is a rare bone disease caused by postzygotic somatic activating
mutations in the GNAS gene, which lead to constitutive activation of adenylyl cyclase and …

Introduction Fibrous dysplasia of bone (FD) is a rare congenital bone disease, due to a
somatic mutation of GNAS. This mutation results in a defect of osteoblast differentiation and …

Activating missense mutations of the GNAS1 gene, encoding the α subunit of the stimulatory
G protein (Gs), have been identified in patients with the McCune–Albright syndrome (MAS; …

McCune‐Albright syndrome is a rare genetic disorder consisting of skin and bone dysplasia
and peripheral endocrinopathies. Little data have been collected regarding bisphosphonate …