Rationale: Paradigm shifting studies have revealed that the heart contains functionally
diverse populations of macrophages derived from distinct embryonic and adult …

Among the diverse populations of myeloid cells that reside within the healthy and diseased
heart, CC chemokine receptor type 2 (CCR2) is specifically expressed on inflammatory …

Rationale: Recent advancements have brought to light the origins, complexity, and functions
of tissue-resident macrophages. However, in the context of tissue injury or disease, large …

Proinflammatory macrophages are important mediators of inflammation after myocardial
infarction and of allograft injury after heart transplantation. The aim of this study was to …

Cardiac macrophages represent a heterogeneous cell population with distinct origins,
dynamics, and functions. Recent studies have revealed that CC Chemokine Receptor 2 …

Paradigm-shifting studies in the mouse have identified tissue macrophage heterogeneity as
a critical determinant of immune responses. In contrast, surprisingly little is known regarding …

Aims Macrophages have a critical and dual role in post-ischaemic cardiac repair, as they
can foster both tissue healing and damage. Multiple subsets of tissue resident and monocyte …

Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well
characterized. Here we identify four populations of cardiac macrophages. At steady state …

It is well established that maladaptive innate immune responses to sterile tissue injury
represent a fundamental mechanism of disease pathogenesis. In the context of cardiac …

Research during the last decade has generated numerous insights on the presence,
phenotype, and function of myeloid cells in cardiovascular organs. Newer tools with …