The peripheral nervous system comprises an infinity of neural networks that act in the
communication between the central nervous system and the most diverse tissues of the …

Resident macrophages are distributed across all tissues and are highly heterogeneous due
to adaptation to different tissue-specific environments. The resident macrophages of the …

Neuropathic pain pathogenesis is not only confined to changes in the activity of neuronal
systems, but also involves neuro-immune interactions mediated by inflammatory cytokines …

Molecular and cellular interactions among spinal dorsal horn neurons and microglia, the
resident macrophages of the central nervous system, contribute to the induction and …

Traumatic peripheral neuropathic pain is a complex syndrome caused by a primary lesion or
dysfunction of the peripheral nervous system. Secondary to the lesion, resident or infiltrating …

Neuropathic pain caused by nerve injury or disease remains a major challenge for modern
medicine worldwide. Most of the pathogenic mechanisms underlying neuropathic pain are …

Although macrophages (MΦ) are known to play a central role in neuropathic pain, their
contribution to cancer pain has not been established. Here we report that depletion of sciatic …

Highlights•Macrophages induce pain via pro-inflammatory cytokines that activate
nociceptors.•Nociceptor neurons activate local macrophages via TLR signaling and CCL2 …

Chronic pain is a refractory health disease worldwide causing an enormous economic
burden on individuals and society. Accumulating evidence suggests that inflammation in the …

A neuroimmune crosstalk is involved in somatic and visceral pathological pain including
inflammatory and neuropathic components. Apart from microglia essential for spinal and …