Transient receptor potential channels (TRP channels) are cation selective transmembrane
receptors with diverse structures, activation mechanisms and physiological functions. TRP …

Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels
have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid …

The mammalian superfamily of transient receptor potential (TRP) channels covers 28
members grouped in six families: TRPC, with C for “canonical”; TRPA, with A for “ankyrin”; …

Rheumatoid arthritis (RA) is characterized by the augment of vascular permeability,
increased inflammatory cells infiltration, dysregulated immune cells activation, pannus …

Transient receptor potential vanilloid (TRPV) channels function to maintain the dynamic
balance of calcium signaling and calcium metabolism in bones. The goal of this study was to …

Osteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide.
Despite its prevalence, our understanding of the underlying mechanisms remains …

Transient receptor potential (TRP) ion channels are expressed in neuronal and some non-
neuronal cells and are involved particularly in pain and thermosensation. We previously …

Intervertebral disc (IVD) degeneration and consequent low back pain (LBP) are common
and costly pathological processes that require improved treatment strategies. Transient …

Objective Transient receptor potential vanilloid 4 (TRPV4) is a Ca2+‐permeable channel
that can be gated by tonicity (osmolarity) and mechanical stimuli. Chondrocytes, the cells in …

Transient receptor potential (TRP) are cation channels expressed in both non-excitable and
excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family …