Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-
gated ion channels constitute the critical detectors and transducers of pain-causing stimuli …

Patients with inflammatory or neuropathic pain experience hypersensitivity to mechanical,
thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of …

Pain results from the complex processing of neural signals at different levels of the central
nervous system, with each signal potentially offering multiple opportunities for …

Nociception is the process of transmission of painful signals by nociceptors in the primary
afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are …

Transient receptor potential (TRP) ion channels are molecular gateways in sensory systems,
an interface between the environment and the nervous system. Several TRPs transduce …

Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a
complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve …

The last decade has witnessed an explosion in novel findings relating to the molecules
involved in mediating the sensation of pain in humans. Transient receptor potential (TRP) …

In ancient times, physicians had a limited number of therapies to provide pain relief. Not
surprisingly, plant extracts applied topically often served as the primary analgesic plan. With …

Historically, drug research targeted to pain treatment has focused on trying to prevent the
propagation of action potentials in the periphery from reaching the brain rather than …

The transient receptor potential (TRP) channel superfamily is comprised of a large group of
cation-permeable channels, which display an extraordinary diversity of roles in sensory …