G protein-coupled receptors: novel targets for drug discovery in cancer

R Lappano, M Maggiolini - Nature reviews Drug discovery, 2011 - nature.com
G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

G-protein-coupled receptors and cancer

RT Dorsam, JS Gutkind - Nature reviews cancer, 2007 - nature.com
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

G protein-coupled receptors in cancer

R Bar-Shavit, M Maoz, A Kancharla, JK Nag… - International journal of …, 2016 - mdpi.com
Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying
receptor family and mediate many physiological processes, their role in tumor biology is …

G protein-coupled receptors as promising cancer targets

Y Liu, S An, R Ward, Y Yang, XX Guo, W Li, TR Xu - Cancer letters, 2016 - Elsevier
G protein-coupled receptors (GPCRs) regulate an array of fundamental biological
processes, such as growth, metabolism and homeostasis. Specifically, GPCRs are involved …

GPCRs: Emerging anti-cancer drug targets

AN Gutierrez, PH McDonald - Cellular signalling, 2018 - Elsevier
G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family
in the human genome with over 800 members identified to date. They play critical roles in …

[HTML][HTML] The current status of anti-GPCR drugs against different cancers

S Usman, M Khawer, S Rafique, Z Naz… - Journal of Pharmaceutical …, 2020 - Elsevier
G protein coupled receptors (GPCRs) have emerged as the most potential target for a
number of drug discovery programs ranging from control of blood pressure, diabetes, cure …

GPCRs and cancer

R Lappano, M Maggiolini - Acta pharmacologica sinica, 2012 - nature.com
G-protein-coupled receptors (GPCRs), which represent the largest gene family in the human
genome, play a crucial role in multiple physiological functions as well as in tumor growth …

Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

V Wu, H Yeerna, N Nohata, J Chiou… - Journal of biological …, 2019 - ASBMB
G protein–coupled receptors (GPCRs) are the largest gene family of cell membrane–
associated molecules mediating signal transmission, and their involvement in key …

An insight into GPCR and G-proteins as cancer drivers

PK Chaudhary, S Kim - Cells, 2021 - mdpi.com
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers

N Arang, JS Gutkind - FEBS letters, 2020 - Wiley Online Library
G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …