[HTML][HTML] Inflammasomes: mechanisms of action and involvement in human diseases
D Bulté, C Rigamonti, A Romano, A Mortellaro - Cells, 2023 - mdpi.com
Inflammasome complexes and their integral receptor proteins have essential roles in
regulating the innate immune response and inflammation at the post-translational level. Yet …
regulating the innate immune response and inflammation at the post-translational level. Yet …
Inflammasome activation: from molecular mechanisms to autoinflammation
S Lara‐Reyna, EA Caseley, J Topping… - Clinical & …, 2022 - Wiley Online Library
Inflammasomes are assembled by innate immune sensors that cells employ to detect a
range of danger signals and respond with pro‐inflammatory signalling. Inflammasomes …
range of danger signals and respond with pro‐inflammatory signalling. Inflammasomes …
Inflammasomes: mechanism of action, role in disease, and therapeutics
H Guo, JB Callaway, JPY Ting - Nature medicine, 2015 - nature.com
The inflammasomes are innate immune system receptors and sensors that regulate the
activation of caspase-1 and induce inflammation in response to infectious microbes and …
activation of caspase-1 and induce inflammation in response to infectious microbes and …
Inflammasomes and their roles in health and disease
M Lamkanfi, VM Dixit - Annual review of cell and developmental …, 2012 - annualreviews.org
Inflammasomes are a set of intracellular protein complexes that enable autocatalytic
activation of inflammatory caspases, which drive host and immune responses by releasing …
activation of inflammatory caspases, which drive host and immune responses by releasing …
Inflammasome biology, molecular pathology and therapeutic implications
F Awad, E Assrawi, C Louvrier, C Jumeau… - Pharmacology & …, 2018 - Elsevier
Inflammasomes are intracellular multiprotein signaling complexes, mainly present in
myeloid cells. They commonly assemble around a cytoplasmic receptor of the nucleotide …
myeloid cells. They commonly assemble around a cytoplasmic receptor of the nucleotide …
Inflammasomes: mechanism of assembly, regulation and signalling
Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
[HTML][HTML] Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
[HTML][HTML] Inflammasomes as therapeutic targets in human diseases
Y Li, H Huang, B Liu, Y Zhang, X Pan, XY Yu… - Signal transduction and …, 2021 - nature.com
Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …
inflammation in response to either exogenous pathogens or endogenous danger signals …
Molecular mechanisms involved in inflammasome activation
C Bryant, KA Fitzgerald - Trends in cell biology, 2009 - cell.com
Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous
products released from damaged or dying cells and trigger innate immunity. In most cases …
products released from damaged or dying cells and trigger innate immunity. In most cases …
The inflammasomes and autoinflammatory syndromes
L Broderick, D De Nardo, BS Franklin… - Annual Review of …, 2015 - annualreviews.org
Inflammation, a vital response of the immune system to infection and damage to tissues, can
be initiated by various germline-encoded innate immune-signaling receptors. Among these …
be initiated by various germline-encoded innate immune-signaling receptors. Among these …