Insulin resistance is a critical pathophysiological process in the onset and advancement of
type 2 diabetes mellitus. It is well-recognized that alterations in the metabolism of lipids and …

Mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been suggested to
play a key role in insulin resistance development. Reactive oxygen species (ROS) …

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) enhance insulin sensitivity and glucose
homeostasis in rodent models of insulin resistance. These beneficial effects have been …

Omega-3 polyunsaturated fatty acids (n-3 PUFA) of marine origin, eicosapentaenoic acid
(EPA), and docosahexaenoic acid (DHA), have been long studied for their therapeutic …

In humans, insulin sensitivity is relatively impaired by diets that are low in oleic acid (OA), a
cis monounsaturated fatty acid (MUFA), or rich in trans MUFA or palmitic acid (PA), a …

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve insulin
sensitivity and glucose homeostasis in animal models of insulin resistance, but the involved …

Abstract Omega-3 and omega-6 groups of polyunsaturated fatty acids (PUFA) are non-
interconvertible and metabolically and functionally different, with key opposing metabolic …

Insulin resistance is a growing worldwide phenomenon, which progressivelydevelops over
years, and finally, if unchecked, predisposes to cardiovascular disease and diabetes …

Insulin resistance is an important risk factor for the development of several cardiac
pathologies, thus advocating strategies for restoring insulin sensitivity of the heart in these …

Purpose Diabetes and cardiovascular disease are major public health concerns worldwide
and are leading causes of morbidity and mortality. People with type 2 diabetes are at an …