Natural and synthetic glucocorticoids (GCs) are widely employed in a number of
inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel …

Inflammatory bowel diseases (IBDs), such as ulcerative colitis and Crohn's disease, are
chronic pathologies associated with a deregulated immune response in the intestinal …

Glucocorticoids are potent inhibitors of T cell activation and proinflammatory cytokines and
are highly effective treatment for active inflammatory bowel disease (IBD). However, failure …

The aim of this study is to investigate the role of single-nucleotide polymorphisms (SNPs) of
the glucocorticoid receptor (GR) and of the related co-chaperone FKBP5 genes in the …

Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn's disease
(CD). IBD etiopathology is multifactorial and involves alteration of immune cells and chronic …

Background: Glucocorticoids (GC) play a major role in the attenuation of inflammation.
Glucocorticoid receptor (GR) expression is an important determinant of steroid sensitivity …

Glucocorticoids (GCs) are the most potent anti-inflammatory agents known. A major factor
limiting their clinical use is the wide variation in responsiveness to therapy. The high doses …

The MDR1 gene is an attractive candidate gene for the pathogenesis of inflammatory bowel
disease (IBD) and perhaps response to therapy, with evidences at both functional and …

Background & Aims: Recently, the glucocorticoid receptor β (hGRβ) was suggested to play a
role as a dominant negative regulator for determining glucocorticoid response. The aim of …

Pro-inflammatory cytokines are involved in the pathogenesis of many inflammatory
diseases, and the excessive expression of many of them is normally counteracted by …