Background The morbidity and mortality of sepsis are extremely high, which is a major
problem plaguing human health. However, current drugs and measures for the prevention …

Sepsis is associated with a high risk of death, and the crosstalk between gut microbiota and
sepsis is gradually revealed. Indole 3-propionic acid (IPA) is a gut microbiota-derived …

Bacterial sepsis is characterized by a rapid increase in the expression of inflammatory
mediators to initiate the acute phase response in liver. Inflammatory mediator release is …

The pregnane X receptor (PXR) is a nuclear receptor transcription factor regulating drug-
metabolizing enzymes and transporters that facilitate xenobiotic and endobiotic …

Endotoxemia‐related acute liver injury has a poor prognosis and high mortality, and
macrophage polarization plays a central role in the pathological process. Pregnane X …

Liver ischemia and reperfusion injury (IRI) is one of the obstacles in liver surgery such as
liver resection and transplantation. In this study, we investigated the preventive effect on …

Hepatic ischemia/reperfusion injury (HIRI) is a serious complication that occurs following
shock and/or liver surgery. Gut microbiota and their metabolites are key upstream …

To improve patient survival in sepsis, it is necessary to curtail exaggerated inflammatory
responses. Fucoxanthin (FX), a carotenoid derived from brown algae, efficiently suppresses …

Sepsis remains a major cause of mortality in intensive care units, better therapies are
urgently needed. Gram-negative bacterial lipopolysaccharide (LPS) is an important trigger of …

Arachidonic acid can be metabolized to prostaglandins and epoxyeicosatrienoic acids
(EETs) by cyclooxygenase-2 (COX-2) and cytochrome P450 (CYP), respectively. While …