[HTML][HTML] Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia

R Marín, DI Chiarello, C Abad, D Rojas… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

The role of mitochondrial dysfunction in preeclampsia: causative factor or collateral damage?

AN Smith, X Wang, DG Thomas… - American journal of …, 2021 - academic.oup.com
Preeclampsia, new onset hypertension in pregnancy, affects~ 5%–10% of the world's
population. Preeclampsia is the leading cause of morbidity and mortality for both the mother …

[HTML][HTML] Mitochondrial role in adaptive response to stress conditions in preeclampsia

PA Vishnyakova, MA Volodina, NV Tarasova… - Scientific reports, 2016 - nature.com
Preeclampsia (PE) is a pregnancy-specific syndrome, characterized in general by
hypertension with proteinuria or other systemic disturbances. PE is the major cause of …

[HTML][HTML] Placental mitochondrial function and dysfunction in preeclampsia

F Jahan, G Vasam, AE Green, SA Bainbridge… - International journal of …, 2023 - mdpi.com
The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational
parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in …

[HTML][HTML] Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery

OJ Holland, JSM Cuffe, M Dekker Nitert… - Cell death & …, 2018 - nature.com
Preeclampsia is a devastating pregnancy disorder. Severity varies widely, and while severe
preeclampsia often requires pre-term delivery, women with mild preeclampsia may reach …

[HTML][HTML] Placental mitochondrial abnormalities in preeclampsia

P Vangrieken, S Al-Nasiry, A Bast, PA Leermakers… - Reproductive …, 2021 - Springer
Abstract Preeclampsia complicates 5–8% of all pregnancies worldwide, and although its
pathophysiology remains obscure, placental oxidative stress and mitochondrial …

Role of mitochondrial dysfunction and reactive oxygen species in mediating hypertension in the reduced uterine perfusion pressure rat model of preeclampsia

VR Vaka, KM McMaster, MW Cunningham Jr… - …, 2018 - Am Heart Assoc
Placental ischemia is believed to be the initial event in the development of preeclampsia.
Mitochondrial dysfunction is a cause of reactive oxygen species (ROS) generation and …

Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia

HW Yung, F Colleoni, E Dommett… - Proceedings of the …, 2019 - National Acad Sciences
Preeclampsia (PE) is a dangerous complication of pregnancy, especially when it presents
at< 34 wk of gestation (PE< 34 wk). It is a major cause of maternal and fetal morbidity and …

[HTML][HTML] Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia

C McCarthy, LC Kenny - Scientific reports, 2016 - nature.com
Aberrant placentation generating placental oxidative stress is proposed to play a critical role
in the pathophysiology of preeclampsia. Unfortunately, therapeutic trials of antioxidants have …

Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy

JJ Fisher, LA Bartho, AV Perkins… - Clinical and …, 2020 - Wiley Online Library
Mitochondria are central to cell function. The placenta forms the interface between maternal
and fetal systems, and placental mitochondria have critical roles in maintaining pregnancy …