Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

Ribosomopathies are congenital diseases with defects in ribosome assembly and are
characterized by elevated cancer risks. Additionally, somatic mutations in ribosomal proteins …

A wealth of novel findings, including congenital ribosomal mutations in ribosomopathies and
somatic ribosomal mutations in various cancers, have significantly increased our …

Ribosomes are a complex ensemble of rRNA and ribosomal proteins that function as mRNA
translation machines. Ribosome biogenesis is a multistep process that begins in the …

Ribosome biogenesis is the most demanding energetic and metabolic expenditure of the
cell. The nucleolus, a nuclear compartment, coordinates rRNA transcription, maturation, and …

Ribosomopathies are diseases caused by defects in ribosomal constituents or in factors with
a role in ribosome assembly. Intriguingly, congenital ribosomopathies display a paradoxical …

Ribosomes are essential components of the protein synthesis machinery. The process of
ribosome biogenesis is well organized and tightly regulated. Recent studies have shown …

Although ribosomal proteins are known for playing an essential role in ribosome assembly
and protein translation, their ribosome-independent functions have also been greatly …

Increasing evidence suggests that alterations in ribosome biogenesis (RiBi) confer
competitive advantages to cancer cells. This has led to the discovery of regulatory layers …

The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …