Due to the close interaction of lung morphology and functions, repeatable measurements of
pulmonary function during longitudinal studies on lung pathophysiology and treatment …

Lungs play the most important role in the gas exchange process by transferring oxygen from
the inhaled air to blood. Any chronic pulmonary abnormality eventually causes …

The role of imaging as a tool for investigating lung physiology is growing at an accelerating
pace. Looking forward, we wished to identify unresolved issues in lung physiology that might …

Recent advances in imaging offer exciting opportunities to develop and validate lung-
specific biomarkers as valuable adjuncts to diagnosis, tests of treatment efficacy, and/or …

Pulmonary function analysis is an important tool in the evaluation of mouse respiratory
disease models, but much controversy still exists on the validity of some tests. Most …

The ICH guideline S7A requires safety pharmacology tests including measurements of
pulmonary function. In the first step–as part of the “core battery”–lung function tests in …

Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function
and may be characteristic of early pulmonary disease. While standard indices like …

Over the past few decades, pulmonary imaging technologies have advanced from chest
radiography and nuclear medicine methods to high-spatial-resolution or low-dose chest CT …

Precise and repeatable measurements of pulmonary function in intact mice or rats are
becoming increasingly important for experimental investigations on various respiratory …

Measuring lung function in mice is essential for establishing the relevance of murine models
to human lung disease. However, making such measurements presents particular technical …